Antipyretic medicine can easily hurt the liver when it comes to coffee!

Scientists have found that caffeine reacts with antipyretic drugs such as paracetamol, causing liver damage. Researchers warn coffee lovers not to drink coffee while taking acetaminophen.

Acetaminophen is the most widely used antipyretic analgesic in the world. It is used for fever caused by common cold and influenza. It can relieve mild to moderate pain, such as joint pain, headache, muscle pain, toothache, dysmenorrhea, neuralgia and so on. Acetaminophen is found in many painkillers, antipyretic drugs and cold medicines, including Sanlitong, Bilitong, Baijiao, Tylenol, Gankang, Suganning, Vitamin C Yinqiao tablets, Happiness Shangfeng, 999 Ganmao granules, quick-acting cold capsules, new quick-acting cold tablets, children's quick-acting cold granules, Baijiahei, Kangbide, Haiwang Yindefei and so on, most of which are over-the-counter drugs.

It is important to be aware that long-term and large doses of acetaminophen alone will also increase the risk of liver failure (see the 18th edition of issue 184, "pain relieving and antipyretic drugs hurt the liver"). For adults, the maximum dose of acetaminophen a day should not exceed 4 grams, otherwise it will cause liver damage; 2 grams a day is generally recommended. The course of treatment of fever is generally no more than 3 days, and pain relief should not exceed 10 days.

Now, American scientists have pointed out that if acetaminophen is mixed with coffee, it may lead to serious consequences. Acetaminophen produces a toxic enzyme during the cleavage of the liver, causing danger to the liver. Caffeine increases the concentration of this toxic substance by three times. In addition, the mixture of acetaminophen and alcohol also cooperated with the toxin to cause liver damage.

In response, Sidney Nielsen, a researcher at the University of Washington in Seattle, said: "when a 'normal person' takes acetaminophen, he will be threatened with side effects only after drinking 20 cups of strong coffee in a day." But patients who are taking antiepileptic drugs and antidepressants are more likely to be affected because these drugs increase the concentration of toxic substances. " Therefore, after taking acetaminophen, it is best not to drink coffee for a short time.