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Why is it uncomfortable for someone to drink coffee?! Take a look at these seven symptoms

Published: 2026-04-24 Author: World Gafei

Last Updated: 2026/04/24, Very few people feel excited after consuming caffeine, which is not directly caused by caffeine. Caffeine binds to the adrenoceptor in the brain, and when it accumulates to a certain amount, it should send a signal to the resting body and allow many natural stimulants such as amines to function unrestricted. The individual sensitivity of the brain to caffeine is very different from that of coffee.

Genetic relationship

Many people feel "excited" after consuming caffeine, which is not directly caused by caffeine. Caffeine binds to the adrenoceptor in the brain, and when it accumulates to a certain amount, it should send a signal to the resting body and allow the function of many natural stimulants such as amines to be unrestricted. The brain's sensitivity to caffeine varies widely among individuals, depending on how much caffeine binds to adrenoceptors. People who can effectively bind to more adrenoceptors tend to be more sensitive. (note: caffeine has a similar shape and chemical structure to adrenaline, and it can also react with adrenoceptor.) I have never drunk so much.

It may sound counterintuitive, but people who do not consume caffeine regularly tend to feel a stronger negative reaction than those who are already tolerant to caffeine. The tolerance to caffeine is based on many retrospective studies, but studies have shown that continuous caffeine intake reduces the production of the brain's mood-enhancing hormone norepinephrine, allowing the body to pursue caffeine, a substance that is both full and empty. The culprit is in the medicine cabinet.

The Mayo Clinic says certain antibiotics, asthma relievers and echinacea (used to prevent colds) can increase the side effects of caffeine. At the same time, antibiotics and echinacea can interfere with the metabolism of caffeine, making it accumulate to a higher concentration in the circulation, and it takes longer to remove it. Asthma relieving drugs-theophylline itself has caffeine-like side effects, and it can be even more uncomfortable when used in combination. When suffering from anxiety disorder

If you are suffering from anxiety disorders in your daily life, large amounts of caffeine may aggravate the symptoms. "caffeine is the most widely used mood-altering drug in the world," said Dr. Roland Griffiths of Johns Hopkins University School of Medicine. In the field of psychiatry, caffeine can cause anxiety and panic disorders (panic disorders), aggravate panic attacks in patients with panic attacks, and cause insomnia in people who are prone to panic attacks. Slow metabolism

There is an enzyme in the liver that helps the body metabolize caffeine, which determines everyone's ability to remove caffeine. Those who produce fewer metabolic enzymes need to spend more time clearing caffeine from the body, which lasts longer and has more and longer side effects. In contrast, people who have a lot of caffeine-metabolizing enzymes tend to need to consume caffeine more frequently to maintain their intended function on the Y chromosome.

Unfortunately, there are also gender differences in the body's ability to handle caffeine, and women are born to metabolize faster than men. In a study at the University of Barcelona, a group of college students standardized caffeine intake for 10 minutes, and when it worked in both men and women, it was found that caffeine had a stronger effect on men when oral contraceptive was used.

Contrary to the belief that women are born with a fast metabolism of caffeine, when women are using oral contraceptive, they may have only the metabolic rate of the previous one and three, making them more sensitive and more likely to cause side effects. Usually, at the end of the metabolic cycle, caffeine is excreted with a certain amount of important minerals in the body, such as calcium, zinc and potassium. Women who are using oral contraceptive lose more minerals because contraceptive hormones inhibit caffeine metabolism, according to a study. So as more nutrients are lost, caffeine and its side effects will last longer in the body.

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