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Science points out that drinking black coffee regularly can effectively reduce the risk of gallstones. Can you drink coffee on an empty stomach?

Published: 2026-05-14 Author: World Gafei

Last Updated: 2026/05/14, Gallstones can inadvertently grow in our bodies, usually due to irregular diet and rest. But the good news today is that drinking about six cups of coffee a day can help reduce the risk of gallstones. Newsweek, published in the Journal of Internal Medicine, based on a study of 114000 Danish participants, collected their similar students.

Gallstones can inadvertently grow in our bodies, usually due to irregular diet and rest. But the good news today is that drinking about six cups of coffee a day can help reduce the risk of gallstones.

Newsweek, published in the Journal of Internal Medicine, based on a study of 114000 participants in Denmark, collected personal information about their similar lifestyles, had a physical examination, and collected DNA in their blood.

After the distribution of allele scores, the researchers studied whether genetic mutations in metabolic coffee were associated with drinking more coffee. The researchers assessed the link between coffee consumption and gallstone cases. They found that people who drank one cup of coffee a day had a 3% lower risk of gallstones, and those who drank six or more cups of coffee were associated with 23 lower cases of gallstones.

In observations and genetic analysis, high coffee intake was associated with a low risk of GSD symptoms in most people. The study is purely observational, so there is no causal relationship between coffee drinking and reducing the risk of gallstones, but the study's authors offer some explanations. this includes the possibility that the body uses bile (which can cause gallstones to accumulate and cause disease) to defuse all caffeine in coffee.

But please be careful not to drink coffee on an empty stomach and to drink less coffee with vegetable fat powder. Drinking the right amount of coffee every day can help prevent gallstones, because coffee can stimulate gallbladder contraction and help empty bile. But drinking coffee on an empty stomach has the opposite effect. Because drinking coffee on an empty stomach will not only stimulate gastric acid secretion, cause damage to gastrointestinal mucosa, but also may affect liver metabolism and cardiovascular system.

More importantly, if there are gallstones or gallbladder polyps that have not yet been discovered, the stimulation brought by drinking coffee on an empty stomach will make the gallbladder contract violently and induce biliary colic. Therefore, people's habit of eating coffee on an empty stomach for breakfast should be changed, and delicious coffee should be left for a rest after dinner.

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