Why do some people drink coffee, such as drinking water, while others have insomnia and palpitations?

Do you drink coffee? "

"No, I can't sleep if I drink so late."

"No, drinking coffee can cause palpitations!"

This is probably the most common saying for non-coffee drinkers, because strange things that happen to coffee drinkers are also common, such as "the man fainted after drinking four bags of instant coffee in eight hours and still had sleepless nights after a month." But also drink coffee, why the reaction in different people is so different?

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Why does someone drink coffee like "drinking boiled water"?

Caffeine is an alkaloid compound and a central nervous stimulant that can block drowsiness, excite spirit and enhance vitality in a short period of time. But in different people, the reaction is different. Take coffee, for example, some people are so sensitive that drinking a little can work, while others drink like plain boiled water.

To find out, Nicola Pilatu of the University of Edinburgh in the UK and his team conducted genome-wide association analysis in two Italian populations. One group has 370 people from a small village in southern Italy, and the other group has 843 people from six villages in northeastern Italy. In the study, the researchers asked Italian subjects how much coffee they consumed each day and repeated the experiment on 1731 independent subjects from the Netherlands.

They found that the expression of a gene called PDSS2 was negatively correlated with coffee consumption. If the protein level of PDSS2 gene is high, the expression of genes related to caffeine metabolic pathway will be inhibited, thus hindering the degradation of caffeine.

The researchers said the new study identified the PDSS2 gene and linked it to coffee consumption, but further research and a larger number of subjects were needed to confirm the results.

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What is a "panic" when drinking coffee?

Some people will feel flustered and pounding after drinking coffee, which is commonly known as palpitations. In fact, this is a more subjective discourse, which may be caused by many physiological changes, such as early atrial contraction, early ventricular contraction, tachycardia and so on, while normal early cardiac contraction has been confirmed by many studies. It is related to the morbidity and mortality of cardiovascular disease.

So does drinking coffee or caffeine cause palpitations? In fact, some studies hold opposing views!

In a study published in the Journal of the American Medical Association, 22 patients with ventricular tachycardia or ventricular fibrillation monitored their electrocardiograms an hour before and after ingesting 275mg caffeine (the equivalent of 1 cup of coffee) and found that caffeine did not induce or aggravate arrhythmias.

In another study, 50 patients with arrhythmias were divided into two groups, one group drank decaffeinated coffee and the other group drank 200mg caffeinated coffee (plus caffeine for decaffeinated coffee) and monitored for 3 hours. There was no difference in palpitation between the two groups.

Therefore, whether you really have an abnormal heartbeat after drinking coffee, it is more reliable to trust your sensory judgment and give it to a professional to diagnose.

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Traditional Chinese medicine gave "high praise" to coffee.

As an exotic tropical plant, coffee was introduced very late in China, and there are few records in traditional Chinese medicine books. From the perspective of traditional Chinese medicine, coffee has a special aroma and bitterness. According to traditional Chinese medicine, aromatic substances have the function of refreshing and refreshing, and bitterness often enters the heart meridian. Drinking coffee often has the effect of refreshing and relieving fatigue, which is very suitable for office workers. Modern medical research also believes that coffee is easy to pass through the blood-brain barrier and stimulate the central nervous system, which can make the mind more clear, responsive and improve work efficiency.

Coffee pungent warm, pungent can dissipate dampness, warm can help yang, so it helps the role of kidney yang, diuresis, can increase urination, improve abdominal distension and edema. Its effect is similar to Cistanche deserticola and other warm traditional Chinese medicine, so modern Chinese medicine with coffee (daily drinking) to treat damp-heat dysentery or benign prostatic hyperplasia with damp-heat, the effect is good. Especially in patients with benign prostatic hyperplasia, drinking coffee often has the effect of relieving pain and anti-hyperplasia.

Coffee can also accelerate metabolism and has the effect of extinguishing wind and relieving spasm. Stroke, Parkinson's disease and other diseases with syncope, tremor and paralysis as the main manifestations, all belong to the category of wind syndrome and spasm syndrome of traditional Chinese medicine, and can drink coffee in the right amount. Modern Chinese medicine research believes that taking broad bean with coffee can effectively control tremor and prevent Parkinson's disease.