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Systematic review of potential adverse effects of caffeine intake

Published: 2026-05-13 Author: World Gafei

Last Updated: 2026/05/13, Professional barista exchanges, please pay attention to coffee workshop (Weixin Official Accounts cafe_style) systematic review to explore the potential adverse effects of caffeine intake in the world's most popular caffeine research report, the first review of caffeine safety assessment written by Nawrot et al. and peer-reviewed in 2003, the most widely cited internationally, also added

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A systematic review of the potential adverse effects of caffeine intake

The most talked about caffeine research report in the world is the review of caffeine safety assessment written by Nawrot et al in 2003 and peer-reviewed (peer-review), which is the most widely cited internationally and is also used by Health Canada as the basis for recommendations for maximum caffeine intake. Although more than 10,000 caffeine-related papers have been published in the more than 10 years since its publication, there has been no comment on caffeine since it was published.

In view of this, ILSI North America decided to update the classic literature and invited 15 experts, including epidemiology, clinical medicine and systematic review, to conduct a systematic review (systematic review) of the potential adverse effects of caffeine published from 2001 to June 2015. The subjects were adults, pregnant women, adolescents and children. The results of acute toxicity, cardiovascular toxicity, effects of bone and calcium, behavior, development and reproduction were compared with the current version of non-adverse effect caffeine intake of Health Canada.

When clarifying and evaluating causality, scientific research pays great attention to the classification of the strength of scientific evidence. If the conclusions of scientific research only come from expert opinions (not supported by empirical data), the intensity of such scientific evidence is the weakest; the credibility of integrated analysis, systematic review and randomized controlled trials located in the upper half of the pyramid is higher because they can provide high intensity of scientific evidence, but the resources required for such research, such as funds, manpower and time, are also relatively high.

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