New insights into how compounds in coffee inhibit prostate cancer

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Some major epidemiological studies in recent years have concluded that moderate coffee consumption is not harmful to most of us, and that drinking a few cups a day may even be beneficial. Although a large number of observational studies have found a possible link between coffee and improved health, such self-reported data do not confirm causality or help us understand exactly how coffee is beneficial.

A new study was presented recently at the European Urology Society Congress in Barcelona, looking at two special compounds in coffee that may inhibit the growth of prostate cancer. The study has been confirmed only in animal models, but the findings may explain why men who drink coffee are less likely to develop prostate cancer.

The new study initially focused on six specific prospective anticancer compounds found in coffee. After testing the compounds on prostate cancer cells, two special compounds have inhibitory effects on cell proliferation at low concentrations. they are carvalenol acetate and caffeine. The researchers found that caffeine acetate and caffeine inhibited the growth of cancer cells in mice, but the combination seemed to act synergistically, causing the tumor to grow significantly slower than in untreated mice.

Of course, this does not mean that people with prostate cancer should immediately start drinking multiple cups of coffee a day as an anti-cancer measure. The researchers do reasonably point out that the work has only been established in animal models and has not yet been tested in humans. The study does confirm that the concentrations of these two specific compounds used in animal studies can be replicated in humans by drinking three cups of Turkish coffee or six cups of mocha.