This substance in coffee can help abolish the risk of developing diabetes.

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In recent years, researchers have identified substances in coffee that may help abolish the risk of developing type 2 diabetes. But a small number of these have been tested in animals. Now it seems that in a study in the journal of the natural product ACS, scientists report that one of these previously untested compounds appears to improve cell function and insulin distinction in laboratory mice. Look for new drugs that can inspire the development of new drugs to treat or even prevent the disease.

Some studies suggest that drinking three to four cups of coffee a day may reduce the risk of developing type 2 diabetes, afflicting nearly 30 million Americans. Initially, scientists suspected that caffeine was responsible for this effect. But the latest findings discount this possibility, suggesting that other substances in coffee may play a more important role. In an earlier laboratory study, Frederick Brustad Mellbye, S ø ren Gregersen and colleagues found an increase in insulin secretion in pancreatic cells of a compound called cafestol in coffee when they showed up in glucose. Cafestol is also effective in increasing glucose in muscle cells when it is a commonly recommended antiglycemic drug. In this new study, researchers will find out whether cafestol will help prevent or delay the onset of type 2 diabetes in mice.

The researchers separately are inclined to develop a second type of diabetes into three groups of mice. Two different doses of cafestol were provided. Ten weeks later, two sets of cafestol mice were provided with lower blood glucose levels and improved insulin secretion compared with the control group, and the compound was not measured. Cafestol also did not cause hypoglycemia or hypoglycemia, a possible side effect of some antiglycemic treatments. The researchers believe that daily consumption of cafestol may delay the onset of type 2 diabetes in these mice, and that it is a good candidate to prevent the development of drugs or in human disease.