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The study found that the advantages and disadvantages of drinking coffee depend on individual genes.

Published: 2026-02-22 Author: World Gafei

Last Updated: 2026/02/22, People often read about coffee in newspapers and magazines, some of which may introduce the disadvantages of drinking too much coffee, and some may tell you how many cups of coffee you need to drink every day to get a certain health benefit, which is hard to judge. But a new study published in the journal Molecular Psychiatry tells us that how much coffee people should drink every day depends on how much coffee they drink.

People often read about coffee in newspapers and magazines, some of which may introduce the disadvantages of drinking too much coffee, and some may tell you how many cups of coffee you need to drink every day to get a certain health benefit, which is hard to judge.

But a new study published in the journal Molecular Psychiatry tells us that the amount of coffee people should drink every day depends on your genes, and that people spontaneously regulate our coffee intake for optimal results.

Researchers from Harvard University's School of Public Health and Bregan Women's Hospital recently conducted a meta-analysis of 120000 coffee drinkers of American, European and African descent.

They found that two genetic variants, POR and ABCG2, are used in caffeine metabolism, and that two other variants, BDNF and SLC6A4, may affect the trigger of caffeine on the body's reward mechanism. The researchers also identified for the first time two genes related to glucose and oil metabolism, GCKR and MLXIPL, which are associated with the effects of caffeine on the nervous system and human metabolism.

According to Marilyn Cornelis, a nutrition research assistant at Harvard University and lead author of the study, the new candidate genes do not come from the genes that people used to focus on, so this is a very important step in the study of coffee. Their research may help identify people who are most likely to benefit from increased or reduced coffee intake.

The new study is based on a study published in the journal American Medical Association that found that "how much coffee you drink is healthy for an individual" depends on an individual's genetic profile.

In the 2006 study, it was found that individuals with the caffeine gene type who drank three cups of coffee a day had a lower risk of heart attack. but for people whose genes are characterized by slow coffee metabolism, their risk of heart attack increases by 36% if they drink three cups of coffee a day. This figure is compared with people who have the same genes but drink only one cup of coffee a day.

The author of the new study, Daniel Chasman, an assistant professor at Bregan Women's Hospital, said his team's findings provide more evidence that genes can affect the effect of caffeine on each individual.

According to him, similar to previous genetic analysis of smoking and alcoholism, this study is also an example of the effects of genes on individual behavior habits.