Coffee healthy caffeine can prevent multiple sclerosis of spinal cord

Treating multiple sclerosis of the spinal cord is one of the most difficult problems in the medical community. Spinal multiple sclerosis is one of the most common forms of multiple sclerosis. Therefore, treatment and prevention of multiple sclerosis of the spinal cord is crucial.

Caffeine prevents mice from developing a disease similar to multiple sclerosis in the human spinal cord, US researchers have reported. The discovery could help develop new ways to prevent and treat multiple sclerosis in the spinal cord.

Jeffrey Mills and others at Cornell University in the United States have found that mice that consume a certain amount of caffeine per day (equivalent to a person drinking 6 to 8 cups of coffee per day) are less likely to suffer from experimental autoimmune encephalomyelitis, which may be the result of caffeine preventing immune cells from entering the central nervous system of mice.

Experimental autoimmune encephalomyelitis is the animal form of multiple sclerosis in the human spinal cord, an autoimmune disease in which the immune system mistakenly attacks the body, causing damage to the brain and spinal nerves.

Previous studies have shown that adenosine plays an important role in the development of multiple sclerosis in the spinal cord, so it may be responsible for helping immune cells enter the central nervous system. Adenosine is widely present in the human body and plays an important role in biochemistry, such as transferring energy and promoting sleep.

The researchers said in a statement that adenosine needs to bind to adenosine receptors to affect the central nervous system, and caffeine can stimulate the central nervous system largely because it binds to adenosine receptors, so caffeine can be used to prevent adenosine from acting.

Studies in mice have also shown that mice lacking adenosine receptors and the enzyme CD73, which is necessary for adenosine synthesis outside the cell, are less likely to develop experimental autoimmune encephalomyelitis. The researchers note that this finding and caffeine's association could help advance research into adenosine based prevention and treatment of multiple sclerosis in the spinal cord.

Armed Police Henan Province Corps Hospital experts pointed out that the treatment of spinal cord multiple sclerosis is divided into acute phase treatment and remission phase treatment. Acute treatment is generally glucocorticoid, mainly including methylprednisolone, dexamethasone, prednisone, but also gamma globulin, with some vitamin B family, mainly vitamin B1 and vitamin B12. If you have diabetes, hypertension, severe digestive tract ulcers, etc., you may aggravate these diseases, you can choose immunosuppressants, such as azathioprine, cyclophosphamide, etc., in remission in order to prevent recurrence can use interferon. Autologous stem cell transplantation is also an option if recurrence occurs after all these treatments have been used.

Stem cell transplantation therapy has the ability of self-replication, can differentiate into at least one functional cell early undifferentiated cells; under certain conditions, stem cells can be directionally differentiated into functional cells in the body, forming any type of tissue and organ, that is, with "plasticity", so it is also known as "source cells","universal cells".

In fact, in the 1950s, stem cell therapy began to be applied clinically, most typically using hematopoietic stem cells to treat multiple sclerosis of the spinal cord. Now, stem cells are being used to treat multiple sclerosis in the spinal cord.