What are the benefits of caffeic acid

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It is reported that caffeoylquinic acid or chlorogenic acid (CQA) is a rich intermediate in lignin biosynthesis in chicory, which can be used to improve human glucose metabolism, but the functional group responsible for this effect in the structure has not been determined.

Kimberly M. Palatini Jackson, Institute of Human Health Plant Research, North Carolina State University, etc., have studied that three kinds of di-O-caffeoylquinic acid inhibit liver glucose production in H4IIE rat hepatoma cells by reducing the expression of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK). These two enzymes are key enzymes in controlling hepatic gluconeogenesis. Direct comparisons between CQA and metabolites (3-caffeoylquinine, caffeine and quinic acid) showed that caffeic acid was responsible for the observed effects. Further analysis showed that the activation of phosphatidylinositol 3 kinase (PI3K) and mitogen activated protein kinase (MAPK) pathways were shared between caffeoylquinic acid and caffeic acid as a way to control gene expression. These compounds promote mitochondrial respiration and cellular metabolism, in part by inducing oxidative phosphorylation and proton leakage.

The results showed that caffeic acid played an important role in inhibiting hepatic gluconeogenesis and hyperglycemia, and finally strengthened the relationship between plant dietary intervention containing caffeic acid and beneficial glucose metabolism.

evidence

There is a very famous study that included 41000 doctors and 86000 nurses. The relationship between the incidence of cardiovascular disease and coffee drinking was investigated among more than 100,000 medical workers.

It was found that people who drank two to three cups of coffee a day were less likely to develop cardiovascular disease. Those who did not drink coffee had a higher risk of cardiovascular disease.

In addition, studies have shown that cancer is also associated with coffee intake.

Why does coffee reduce our risk of cardiovascular disease? The conclusion of a study is very interesting, it turns out that it is not caffeine that reduces the risk of cardiovascular disease and tumor in coffee, it is caffeic acid that works!

Caffeic acid can reduce microinflammation. For example, irradiating rats with ultraviolet rays will produce a lot of inflammatory factors in their bodies. When we let it eat coffee, we can see that these inflammatory factors induced by ultraviolet rays are reduced. In other words, drinking coffee can reduce levels of inflammatory factors and reduce microinflammation, which may explain why drinking coffee can protect our cardiovascular system and reduce the risk of cancer.

Everyone can drink some coffee every day as much as they like. Not only is it refreshing, it can also reduce the risk of cardiovascular disease and cancer, and the mechanism behind it is to reduce microinflammation through caffeic acid.